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. 2009 Oct 12;588(Pt 1):93–99. doi: 10.1113/jphysiol.2009.179382

Figure 1. Examples of LTP and LTD of NMDARs.

Figure 1

Tetanic stimulation consisting of eight trains each of eight pulses at 200 Hz, inter-train interval 2 s, applied under current clamp configuration at resting membrane potential during tetanus induces LTP of NMDA-EPSCs in dentate gyrus granule cells (reproduced from O’Connor et al. 1994 with permission from Nature Publishing Group). On the other hand, a 1 Hz stimulation for 10 min while holding the cells at −40 mV induces LTD of NMDA-EPSCs in CA1 area of the hippocampus (reproduced from Selig et al. 1995 with permission from Elsevier).