Figure 6. Time course of changes in respiratory nerve burst frequency in experimental groups.
Changes in phrenic nerve burst frequency from baseline (Δfrequency; bursts min−1) in rats receiving spinal (A) and intravenous (B) treatments: vehicle with AIH (♦ aCSF or saline, respectively), MSX-3 with AIH (▪), MSX-3 time-control without AIH (□) and vehicle control without AIH (♦). Phrenic burst frequency in rats receiving AIH increased from baseline at 60 min post-AIH, indicative of frequency LTF. However, this response was unaffected by MSX-3. #Different from baseline; ‡different from MSX-3 ctrl, *different from vehicle ctrl; RMANOVA; P < 0.05.