Table 8.
DAVID analysis for Gene Ontology terms enriched in the top 50 genes (ranked by fold change) that were up- or downregulated by cyclic hyperoxia in each strain
| GO term | Number of genes | Fold enrichment a | False Discovery Rate b |
|---|---|---|---|
| F344 | |||
| Cellular carbohydrate catabolic process | 8 | 9.6 | 0.033 |
| Carbohydrate catabolic process | 8 | 9.1 | 0.049 |
| SD | |||
| Glycolysis | 8 | 18.6 | 3.72E-04 |
| Glucose catabolic process | 8 | 15.9 | 0.0011 |
| Response to hypoxia | 8 | 15.6 | 0.0013 |
| Hexose catabolic process | 8 | 15.2 | 0.0015 |
| Monosaccharide catabolic process | 8 | 15.2 | 0.0015 |
| Alcohol catabolic process | 8 | 14.7 | 0.0019 |
| Cellular carbohydrate catabolic process | 8 | 11.8 | 0.0083 |
| Glucose metabolic process | 9 | 11.4 | 0.0019 |
| Carbohydrate catabolic process | 8 | 11.1 | 0.0122 |
| Monosaccharide metabolic process | 11 | 11.0 | 8.62E-05 |
| Hexose metabolic process | 10 | 10.1 | 9.22E-04 |
| Soluble fraction | 9 | 7.3 | 0.0378 |
| Alcohol metabolic process | 12 | 7.1 | 0.0013 |
| Cellular carbohydrate metabolic process | 12 | 6.9 | 0.0018 |
| Carbohydrate metabolic process | 13 | 5.3 | 0.0072 |
GO terms are ranked by fold enrichment
aThe ratio between the frequency of term-annotated genes in the query gene list compared to the reference gene list, in this case the rat genome
bThe expected percentage of false positives in a given proportion of genes considered to be significant