Table 9.
Known hypoxia-regulated genes identified from the top fifty genes (ranked by fold change) that were downregulated by cyclic hyperoxia in each strain compared to room air exposure
| Gene | Gene description | Fold change |
|---|---|---|
| Genes downregulated by hyperoxia in F344 rats | ||
| Adra1b | Adrenergic, alpha-1B-, receptor | −2.12 |
| Igfbp2 | Insulin-like growth factor binding protein 2 | −1.86 |
| Slc16a3 | Solute carrier family 16, member 3 | −1.86 |
| Cox4i2 | Cytochrome c oxidase subunit IV isoform 2 | −1.58 |
| Genes downregulated by hyperoxia in SD rats | ||
| Slc16a3 | Solute carrier family 16, member 3 | −4.10 |
| Igfbp2 | Insulin-like growth factor binding protein 2 | −3.42 |
| Hk2 | Hexokinase 2 | −2.95 |
| Pfkfb3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | −2.80 |
| Egln3 | EGL nine homolog 3 | −2.79 |
| Bnip3 | BCL2/adenovirus E1B 19 kDa-interacting protein 3 | −2.63 |
| Cox4i2 | Cytochrome c oxidase subunit IV isoform 2 | −2.45 |
| Pdk1 | Phosphoglycerate kinase 1 | −2.31 |
| Vegfa | Vascular endothelial growth factor A | −2.23 |
| P4ha1 | Procollagen-proline, 2-oxoglutarate 4-dioxygenase | −2.20 |
| Mif | Macrophage migration inhibitory factor | −2.01 |
| Ak3l1 | Adenylate kinase 3-like 1 | −1.97 |
| Pfkl | Phosphofructokinase, liver | −1.93 |
| Tpi1 | Triosephosphate isomerase 1 | −1.89 |
| Egln1 | EGL nine homolog 1 | −1.72 |
| Bhlhb2 | Basic helix-loop-helix family, member e40 | −1.67 |
| Ldha | Lactate dehydrogenase A | −1.62 |
| Pgk1 | Phosphoglycerate kinase 1 | −1.61 |
| Aldoa | Aldolase A, fructose-bisphosphate | −1.57 |
| Gpi | Glucose phosphate isomerase | −1.56 |
Only genes downregulated by 1.5-fold or greater are shown