Table 3.
Relative risk (RR) and 95% confidence interval of postmenopausal breast cancer associated with quartiles of circulating CSF1 in the Nurses' Health Study (1992–1998) according to tumor characteristics.
| Q1 | Q2 | Q3 | Q4 | P-trend1 | P-Het | |
|---|---|---|---|---|---|---|
| Postmenopausal only | ||||||
| In Situ | ||||||
| Cases/controls | 33/155 | 25/155 | 20/157 | 28/155 | ||
| Matching factors | 1.0(Ref) | 0.75(0.42–1.34) | 0.65(0.35–1.20) | 0.88(0.50–1.55) | 0.86 | |
| MV2 RR | 1.0(Ref) | 0.79(0.43–1.45) | 0.67(0.35–1.28) | 1.05(0.56–1.97) | 0.82 | |
| Invasive | ||||||
| Cases/controls | 117/155 | 111/155 | 109/157 | 151/155 | ||
| Matching factors | 1.0(Ref) | 0.97(0.69–1.37) | 0.94(0.66–1.33) | 1.31(0.94–1.83) | 0.12 | |
| MV2 RR | 1.0(Ref) | 1.02(0.71–1.47) | 0.96(0.67–1.38) | 1.45(1.02–2.07) | 0.06 | |
| ER+/PR+ | 0.03 | |||||
| Cases/controls | 60/155 | 64/155 | 63/157 | 90/155 | ||
| Matching factors | 1.0(Ref) | 1.10(0.72–1.68) | 1.15(0.76–1.74) | 1.45(0.96–2.18) | 0.10 | |
| MV2 RR | 1.0(Ref) | 1.21(0.78–1.88) | 1.21(0.78–1.87) | 1.72(1.11–2.66) | 0.04 | |
| ER+/PR− | ||||||
| Cases/controls | 8/155 | 15/155 | 9/157 | 11/155 | ||
| Matching factors | 1.0(Ref) | 1.85(0.75–4.58) | 1.24(0.45–3.40) | 1.38(0.53–3.60) | 0.85 | |
| MV2 RR | 1.0(Ref) | 2.17(0.83–5.72) | 1.48(0.51–4.28) | 1.52(0.53–4.34) | 0.97 | |
| ER−/PR− | ||||||
| Cases/controls | 25/155 | 18/155 | 11/157 | 21/155 | ||
| Matching factors | 1.0(Ref) | 0.83(0.43–1.58) | 0.56(0.27–1.16) | 0.81(0.42–1.56) | 0.32 | |
| MV2 RR | 1.0(Ref) | 0.80(0.41–1.58) | 0.50(0.24–1.06) | 0.70(0.34–1.44) | 0.16 |
1
P for trend based on the log transformed continuous measure of circulating CSF1.
2
Unconditional model adjusted for matching factors and benign breast disease, BMI at age 18, weight gain, parity/age at first birth, alcohol, family history of breast cancer, age at menarche, age at menopause, duration of PMH use.