Table 1.
Overview of frequently used histone deacetylase inhibitors that are available for clinical and research purposes.
| Substance groups | Derivatives | Isotype |
|---|---|---|
| Hydroxamates | Trichostatin A (TSA) | I, II |
| Suberoylanilide hydroxamic acid (SAHA, vorinostat) | I, II, IV | |
| LBH589 (panobinostat) | I, II, IV | |
| PCI24781 (CRA-024781) | I, IIb | |
| LAQ824 | I, II | |
| PXD101 (belinostat) | I, II, IV | |
| ITF2357 | I, II | |
| SB939 | Unknown | |
| JNJ-16241199 (R306465) | I | |
| m-carboxycinnamic acid bishydroxamide (CBHA) | ||
| Scriptaid | ||
| Oxamflatin | ||
| Pyroxamide | ||
| Cyclic hydroxamic acid containing peptides (CHAPs) | ||
|
| ||
| Short chain fatty acids | Butyrate | I, IIa |
| Valproate | I, IIa | |
| AN-9 | ||
| OSU-HDAC42 | ||
|
| ||
| Benzamides | MS-275 (entinostat) | 1, 2, 3, 9 |
| MGCD0103 | 1, 2, 3, 11 | |
| Pimelic diphenylamide | 1, 2, 3 | |
| M344 | ||
| N-acetyldinaline (CI-994) | ||
|
| ||
| Cyclic tetrapeptides | Apicidine | I, II |
| Trapoxins | ||
| HC-toxin | ||
| Chlamydocin | ||
| Depsipeptide (FR901228 or FK228) (romidepsin) | 1, 2, 4, 6 | |
|
| ||
| Sulfonamide anilides | N-2-aminophenyl-3-[4-(4-methylbenzenesulfonylamino)-phenyl]-2-propenamide | |
|
| ||
| Others | Depudecin | |
| NDH-51 | ||
| KD5150 | Pan-HDACI | |
Class I: HDAC1, -2, -3 and -8; class IIa: HDAC4, -5, -7, and -9; class IIb: HDAC 6, and -10; class III: SIRT1-7; class IV: HDAC11.