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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Mol Cell. 2007 Sep 21;27(6):962–975. doi: 10.1016/j.molcel.2007.08.008

Figure 7. Model for RASSF1A Activation of puma Expression.

Figure 7

Fas activation releases MST2 from the inhibitory complex with Raf-1 and induces binding to RASSF1A, leading to MST2 activation. RASSF1A further promotes the interaction of MST2 with its substrate, LATS1. This in turn induces the phosphorylation of YAP1 by LATS1 and dissociation. YAP1 phosphorylation increases the affinity for p73, permitting YAP1 to form a nuclear complex with p73, which induces the transcription of the proapoptotic puma gene.