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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Nat Rev Immunol. 2009 Jul 3;9(8):556. doi: 10.1038/nri2586

Figure 2. IL-17R binding complex and strategies for blockade.

Figure 2

The IL-17R complex contains an undetermined number of IL-17RA and IL-17RC subunits, although studies so far indicate that it might be at minumum trimeric, which is the form shown here. Both IL-17A and IL-17F signal through these subunits, although IL-17A has far higher affinity for IL-17RA than for IL-17RC, whereas IL-17F has a somewhat greater affinity for IL-17RC than for IL-17RA 21. There are multiple anti-cytokine strategies proposed designed to block signalling through the IL-17 receptor 92. Antibodies specific for individual ligands or the individual receptor subunits represent the most straightforward approach. Additionally, soluble IL-17R subunits such as fusions to IgG-Fc have been evaluated in pre-clinical models (reviewed in Ref. 93). Finally, preventing receptor assembly by means of soluble PLAD peptides is another possible avenue for drug development, analogous to approaches used with TNFR signalling 47,50.