Figure 3. Comparison of the action of ANP (hatched bars) to increase albumin clearance in mice with endothelial-specific KO of the ANP GC-A receptor (open bars) and their control littermates (dark bars).

The format is the same as used in Fig. 2 for the wild type mice. In KO mice, ANP does not significantly increase normalized albumin clearance relative to vehicle controls. On the other hand, normalized albumin clearance in the presence of ANP is significantly increased in control littermates relative to the vehicle control (*) and relative to ANP-treated KO mice for back skin, tail and hamstring muscle (**). Note that the units of the 30 min clearance are μl (g dry weight)⁻¹. Thus, a 30 min clearance is a real clearance (expressed as a rate (ml g⁻¹ min⁻¹) multiplied by a measuring time (min).