Figure 5. Mean values of 35 kD Gadomer contrast agent apparent permeability coefficients in masseter muscle tissue and skin of control and EC GC-A KO mice before (open bars) and after (hatched bars) infusion of ANP.

Using the slope/step method in Fig. 4, paired measurements of Gadomer tracer permeability were made before and after ANP infusion in mice later used for the two-tracer isotope uptake methods summarized in Fig. 3. ANP increased cheek skin permeability coefficient (*P < 0.05) and there was a small increase in muscle. In the presence of ANP there was no significant permeability increase in skin or muscle of EC GC-A KO mice.