Table 3.
Names and role of candidate genes in AD
| Gene Symbol | Gene Name | Candidate Rationale |
|---|---|---|
| PZP | Pregnancy Zone Protein | closely related to A2M, maps to the same region |
| A2MP | Alpha 2 Macroglobulins of pregnancy | PZP analog, may participate in cardiovascular remodeling |
| LRP1 | Low density lipoprotein receptor-related protein 1 | APOE receptor related protein |
| CTNNA3 | Catenin, Alpha-3 | alpha-T-catenin binds beta-catenin; beta-catenin interacts with PSEN1 |
| LRRTM3 | Leucine rich repeat transmembrane 3 | nested gene in CTNNA3 |
| NCSTN | Nicastrin | forms complex with PS1 and 2 |
| COG2 | Component of oligomeric golgi complex 2 | essential component of intracellular protein trafficking |
| AGT | Angiotensinogen | enzymatic target of ACE |
| A2M | Alpha 2 Macroglobulin | mediates the clearance of Aβ, |
| APOE | Apolipoprotein Epsilon | validated AD association, VLDL transport |
| ACE | Angiotensinogen converting enzyme | associations found previously between ACE and AD, also mediates Aβ clearance |