Table 4.
Nominally and statistically significant uncorrected single-locus associations with LOAD
| Gene | rs number | risk allele | family allele | family genotype | CC allele | CC genotype | Fisher's allele | Fisher's genotype |
|---|---|---|---|---|---|---|---|---|
| LRP1 | rs9669595* | A | 0.023 | 0.103 | - | - | - | - |
|
|
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| CTNNA3 | rs7911820* | G | 0.016 | 0.083 | - | - | - | - |
| CTNNA3 | rs12357560* | C | 0.06 | 0.041 | - | - | - | - |
| CTNNA3 | rs7074454* † | C | 0.005 | 0.048 | - | - | 0.006 | 0.087 |
| CTNNA3 | rs6480140§ † | C | - | - | 0.613 | 0.008 | 0.706 | 0.007 |
| CTNNA3 | rs997225§ | A | - | - | 0.033 | 0.082 | - | - |
|
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| LRRTM3 | rs1925617* ‡ † | T | 0.652 | 0.001 | - | - | 0.618 | 0.004 |
|
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| NCSTN | rs2038781* | G | 0.052 | 0.031 | - | - | - | - |
|
|
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| A2M | rs1800433‡ | A | - | - | - | - | - | - |
| A2M | rs3832852* † | del | 0.002 | 0.002 | - | - | 0.013 | 0.009 |
|
|
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| APOE | ε2, ε3, ε4* † | ε4 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |
|
|
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| ACE | rs4291* ‡ | A | 0.015 | 0.038 | - | - | - | - |
| ACE | rs4295* | G | 0.068 | 0.058 | - | - | - | - |
| ACE | rs4311 | T | 0.106 | 0.056 | - | - | - | - |
| ACE | rs4646994* † | ins | 0.017 | 0.116 | - | - | 0.009 | 0.066 |
| ACE | rs4343* § † | A | 0.01 | 0.069 | 0.048 | 0.144 | 0.004 | 0.056 |
| ACE | rs4353* † | G | 0.04 | 0.152 | - | - | 0.022 | 0.132 |
| ACE | rs4978* † | C | 0.008 | 0.048 | - | - | 0.012 | 0.093 |
*
Nominally significant at alleles or genotypes in family sample
§
Nominally significant at alleles or genotypes in case-control sample
‡
Part of Significant MDR-PDT models
†
Significant by Fisher’s merged p-value statistic