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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Cancer Prev Res (Phila). 2009 Jan 20;2(2):143–152. doi: 10.1158/1940-6207.CAPR-08-0099

Fig. 1.

Fig. 1

Structures of tocopherols (A) and effects of γ-TmT treatment (0.3% in the diet) on tocopherol levels in the plasma, colon tissues, and feces of the AOM/DSS–treated mice. Samples from experiment 1 were used. Levels of α-T, γ-T, and δ-T were determined according to Materials and Methods, and typical chromatograms of mouse samples and standard plasma (from human) at the 500 mV channel are shown (B). The detection limit of each tocopherol in our analysis was 0.02 ng. For a clear illustration, the baseline of each sample is set at an arbitrary level. Levels of α-T, γ-T, and δ-T in the plasma (C, n = 10/group) of AOM/DSS–treated mice sacrificed at day 3, day 7, and week 7, as well as in the colon homogenates (D, n = 9/group) and feces (E, n = 3/group) of AOM/DSS–treated mice on week 7, are shown as mean ± SE of each group. All three tocopherols were detected in all the samples, but the value of certain tocopherols were too low to be shown in the figures. Several unknown peaks between 14 and 18 min were observed in the colon samples from the γ-TmT–treated mice (B). Different superscripts (a, b, and c) indicate statistical difference among levels of each specific tocopherol (by one-way ANOVA; P < 0.05). *, statistical difference between the γ-TmT–treated and the control group in a specific tocopherol (P < 0.05 by the two-tailed t test).