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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Cancer Prev Res (Phila). 2009 Jan 20;2(2):143–152. doi: 10.1158/1940-6207.CAPR-08-0099

Fig. 2.

Fig. 2

Effects of γ-TmT treatment (0.3% in the diet) on colon adenoma formation in AOM/DSS–treated CF-1 mice. Formalin-fixed visible tumors were dissected, embedded, and sectioned for histopathological analysis. Two H&E-stained sections per tumor were analyzed. All of the individual colon tumors were histologically characterized as tubular adenomas. Scatter plot for the number of colon adenomas per mouse in AOM/DSS–treated mice on week 7 (A, n = 10/group). One mouse in the γ-TmT–treated mice had 15 adenomas in the colon (x), and the number was identified as an extreme outlier (by Q-spread analysis); it was therefore excluded for subsequent statistical analysis. A two-tailed t test yields P = 0.09 and a one-tailed t test yields P = 0.04 when all animals were included. The numbers of colon adenomas with mild, moderate, and severe dysplasia per mouse are also shown as mean ± SE in B. *, the value is different from that in the control group (P ≤ 0.05 by the two-tailed t test).