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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Virology. 2007 Nov 26;372(1):107. doi: 10.1016/j.virol.2007.10.016

Table 2. Anti-LCMV activity of APs is sequence independent.

LCMV pseudotypes (MOI = 1) were pre-incubated with increasing concentrations of 40-mers phosphorothioate oligonucleotides with the indicated sequences for one hour on ice and added to monolayers of VeroE6 cells in 96 well plates. After 48 h, infection was quantified and IC90 calculated as in Table 2 (n = 3 ± SD).

Sequence IC90 (μM, mean + SD)
LCMV ARM53b LCMV cl-13
G40 PS 18.2 ± 4.1 16.7 ± 2.9
A40 PS 4.12 ± 0.92 3.29 ± 1.27
T40 PS 0.311 ± 0.043 0.795 ± 0.121
C40 PS 2.13 ± 0.42 1.91 ± 0.38
I40 PS 0.284 ± 0.031 0.567 ± 0.161
TG20 PS 0.218 ± 0.081 0.367 ± 0.143
AC20 PS 0.812 ± 0.196 1.34 ± 0.048
TC20 PS 0.789 ± 0.221 0.923 ± 0.316
AG20 PS 0.534 ± 0.163 0.845 ± 0.164
C20 PS 11.6 ± 2.0 13.6 ± 4.5
C30 PS 1.84 ± 0.54 2.26 ± 1.01
C50 PS 0.946 ± 0.207 1.12 ± 0.25
C60 PS 0.981 ± 0.197 1.26 ± 0.32