Table 2.
Multivariate1 associations of risk factors among AIAN for low eGFR and albuminuria
| Risk factors |
Low eGFR2 (n = 2,725) adjusted odds ratio (95% CI) |
Albuminuria3,4 (n = 2,271) adjusted odds ratio (95% CI) |
|---|---|---|
| Age (years) | ||
| 18–45 | 1.00 | 1.00 |
| 46–60 | 3.01 (2.09–4.32) | 0.78 (0.58–1.05) |
| ≥61 | 8.42 (5.92–11.98) | 1.01 (0.73–1.38) |
| Male | 0.65 (0.49–0.85) | 1.28 (0.98–1.67) |
| Diabetes | 1.19 (0.94–1.51) | 2.04 (1.57–2.64) |
| Hypertension | 2.38 (1.74–3.26) | 2.63 (1.93–3.59) |
| Obesity | 0.94 (0.74–1.18) | 0.93 (0.72–1.20) |
| Current or former smoker | 1.17 (0.92–1.49) | 1.06 (0.81–1.37) |
| Family history of diabetes | 0.68 (0.52–0.88) | 0.99 (0.73–1.35) |
| Family history of kidney disease | 1.12 (0.87–1.46) | 1.02 (0.77–1.35) |
| Region | ||
| West | 1.00 | 1.00 |
| Northeast | 4.76 (3.16–7.17) | 1.08 (0.67–1.73) |
| Midwest | 2.06 (1.44–2.94) | 0.65 (0.45–0.94) |
| South | 2.09 (1.55–2.82) | 0.72 (0.54–0.96) |
1
Fully adjusted model in which all variables of interest were adjusted simultaneously.
2
eGFR <60 ml/min/1.73 m2.
3
Albumin to creatinine ratio ≥30 mg/g with an eGFR ≥60 ml/min/1.73 m2.
4
Excludes eGFR <60.