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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Neuropharmacology. 2009 Dec 17;58(4-5):683. doi: 10.1016/j.neuropharm.2009.12.004

Figure 2.

Figure 2

Portrayed here is a molecular pathway analysis of genes regulated in the mouse nucleus accumbens by a direct infusion of the HDAC inhibitor MS-275 after chronic social defeat stress. Infusion of MS-275 promotes antidepressant-like behavioral responses and significantly regulates genes as revealed by microarray analysis. Examples of highly regulated molecular pathways that may provide novel targets for treating depression include genes that encode presynaptic vesicular proteins, plasma membrane receptors, intracellular signaling molecules, proteins that regulate the actin cytoskeleton, and the transcriptional regulatory machinery. Reprinted with permission from The Journal of Neuroscience (Covington et al., 2009).