Figure 1. Lymphopenia occurs at equivalent levels following either LCMV-Arm53b or LCMV-Cl 13 infection.

(A) Infection with 2×10⁶ PFU i.v. of either LCMV-Arm53b or LCMV -Cl 13 causes a decrease in circulating CD4⁺ and CD8⁺ T cells on day 3 post-infection, when compared to uninfected mice. (B–D) Mice infected with varying doses of LCMV-Arm53b (shaded triangles) or -Cl 13 (shaded circles) exhibit an equivalent degree of lymphopenia regardless of virus strain or inoculation dose. Total number of cells (B), CD4⁺ (C) and CD8⁺ (D) T cells in the blood from infected mice are reduced on day 3 post-infection, compared to uninfected mice. (B–D) Uninfected mice are represented by the shaded boxed area, which represents the average number of cells ± SEM. 4 mice were used per group and data is represented as average ± SEM.