Table 1.

Concentrations and Aggregation Indexes for Nebulized pf-mtPA

Block	pf-mtPA (mg/mL, mean ± SE)	Aggregation Index (AI, mean ± SE)
1	1.151 ± 0.028	4.1 ± 1.5
2	1.179 ± 0.009	7.1 ± 0.9
3	1.182 ± 0.022	8.0 ± 0.8
4a	0.833 ± 0.089	4.1 ± 1.5
5b	1.411 ± 0.023	5.7 ± 0.8
6c	1.471	4.4
end materiald	1.385 ± 0.034	6.5 ± 0.3

^aThe mean mtPA concentrations in block 4 and 5 were lower and higher, respectively, compared with those of the other blocks (p ≤ 0.0017).

^bThe mean mtPA concentrations in block 4 and 5 were lower and higher, respectively, compared with those of the other blocks (p ≤ 0.0017).

^cmaterial was only nebulized once during this block

^dend material represents nebulized pf-mtPA that was nebulized and collected during block 1, stored (−4°C) and was assayed at the completion of block 6