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. Author manuscript; available in PMC: 2011 Feb 26.
Published in final edited form as: J Mol Biol. 2009 Dec 21;396(3):602. doi: 10.1016/j.jmb.2009.12.020

Figure 1.

Figure 1

Characterization of the complexin-SNARE quaternary complex. A. The fusion clamp model proposes that complexin can replace the C terminus of VAMP2 upon binding to the trans-SNARE complex (adapted from ref. 34). Positions 69, 76, 83, 86 and 89 are the spin-labeled sites of the soluble VAMP2. Positions 35 and 28 of complexin have also been shown in the model. Positions 42, 25 and 22, which are located at the N-terminal of complexin, have not been shown. B. The flow diagram of purification of the complexin-SNARE quaternary complex. C. SDS-PAGE analysis of the purified complexin-SNARE quaternary complex.