Table 2.
Survival of orally immunized mice following aerosol challenge with SCHU S4.
| Mouse strain | vaccine | Time to death of individual mice (days) |
Median time to death (days) |
|---|---|---|---|
| BALB/c | none | 5,5,5,5,5,5 | 5 |
| BALB/c | LVS | 5,5,5,7,7 | 5 |
| BALB/c | SCHU AV | 5,5,5,5 | 5 |
| BALB/c | SCHU S4 Δ0918ΔcapB | 5,5,5,7,7 | 5 |
| BALB/c | SCHU S4ΔclpB | 9,9,16,>28,>28 | 161 |
| BALB/c | SCHU S4ΔiglC | 5,5,5,5,5 | 5 |
| C3H/HeN | none | 5,5,5,5,5,5 | 5 |
| C3H/HeN | LVS | 4,5,5,5,5 | 5 |
| C3H/HeN | SCHU AV | 5,5,5,5,5 | 5 |
| C3H/HeN | SCHU S4Δ0918ΔcapB | 5,5,5,5 | 5 |
| C3H/HeN | SCHU S4 ΔclpB | 5,9,12,13,16 | 121 |
| C3H/HeN | SCHU S4ΔiglC | 5,5,5,6,6 | 5 |
Mice were immunized per os with 108 CFU of one or other vaccine and challenged 6 weeks later by aerosol with 20 CFU of SCHU S4.
1
significantly greater survival (P≤0.03) than for naive mice or mice of the same strain immunized with any of the other vaccine strains.