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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Toxicol Lett. 2009 Dec 1;192(3):387. doi: 10.1016/j.toxlet.2009.11.016

Fig. 2. In vivo activation of KC at 1 hr post-APAP challenge.

Fig. 2

(A) KC and LSEC were purified via FACS from NPC isolated from female C57Bl/6J mice treated with either saline or APAP (350 mg/kg) at 1 hr post-treatment. Total RNA was extracted and the mRNA expression of inflammatory mediators by KC and LSEC was determined by RT-PCR analysis. Densitometric quantification of (B) TNF-α, (C) IL-6 and (D) IL-1β mRNA expression by KC. * P < 0.05, compared with KC isolated from saline-treated mice.