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Inhibition of Class IIa HDACs by acetylated lysine based substrates. Inhibition of trifluoroacetyl-lysine substrate 6 processing by (a) acetyl-lysine substrate 3 (b) acetyl-lysine substrate 21 is presented in dose-response format for Class IIa HDACs. Data represent mean values of triplicate measurements ± s.d. IC50 curves were fit by logistic regression.
