Table 1.

Severity of the mutator effects of mutations affecting the fidelity of yeast Pol α, δ, ε and ζ^*.

Allelle	Pol defect	Alone	With defect of Pol ε Exo	With defect of Pol δ Exo	With defect of MMR
pol1-L868M	base selection	very weak	weak, additivity	strong, synergy	very strong, synergy
pol2-M644G	base selection	weak	very strong, synergy	very strong, synergy	very strong, synergy
pol3-L612M	base selection	weak	weak, additivity	catastrophic**, synergy	very strong, synergy
rev3-L979F	base selection	very weak	weak, additivity	weak, additivity	weak, additivity
pol2-4	proofreading	moderate	n/a	catastrophic**, synergy y	very strong, synergy
pol3-01	proofreading	very strong	catastrophic**, synergy	n/a	catastrophic**, synergy nergy
pol3-5DV***	proofreading	strong	catastrophic**, synergy rgy	n/a	catastrophic**, synergy nergy

^*The compilation is based on [55,56,58,60,67,69,71,73,77,79,86,100] and unpublished observations from Y. Pavlov’s lab.

^**mutation catastrophe - haploids die because of accumulation of lethal lesions and mutations rates could be measured in diploids only

^***original name for this allele[58]. In newer literature, it is often referred to as pol3-D520V, because it leads to D520 → V amino acid change[101].