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. Author manuscript; available in PMC: 2011 Feb 28.
Published in final edited form as: Stat Med. 2010 Feb 28;29(5):546–557. doi: 10.1002/sim.3798

Table 6.

Comparison of the joint model and the separate analysis of the longitudinal outcome when the underlying distribution of ai is multivariate t with d.f. = 5 (n = 500)

Separate Joint

Parameter True Bias SE CP Bias SE CP MSES/MSEJ
Longitudinal
 Fixed effects
β 1 −1 0.400 0.183 0.405 −0.027 0.104 0.895 16.76
β 2 1.5 0.029 0.233 0.950 0.029 0.201 0.975 1.337
β 3 0.8 −0.275 0.362 0.825 −0.065 0.182 0.895 5.533
α 2 0 0.005 0.182 0.945 −0.001 0.149 0.960 1.493
θ 1 −0.5 0.037 0.109 0.935 −0.011 0.107 0.930 1.145
θ 2 1 0.036 0.122 0.940 −0.003 0.097 0.950 1.718
Survival
 Fixed effects
γ 11 0.8 −0.031 0.144 0.800 0.016 0.109 0.970 1.788
γ 12 −1 0.034 0.245 0.865 −0.020 0.194 0.945 1.609
γ 21 0.5 −0.002 0.138 0.925 0.011 0.094 0.965 2.127
γ 22 −1 −0.031 0.234 0.925 −0.025 0.178 0.935 1.725
 Random effects
ν 2 0.5 0.103 0.909 0.870 0.019 0.214 0.950 18.13

Note: Large bias and poor CP are highlighted in boldface.