Table 4.
GO annotations of eight DEC genes identified from colon dataset by MIClique.
| Gene Symbol | Ontology | GO Terms | |
|---|---|---|---|
| DESMIN | Biological process | Cytoskeleton organization; muscle contraction; regulation of heart contraction | |
| Cellular component | Z disc | ||
| Molecular function | Protein binding; structural constituent of cytoskeleton | ||
| CD37 | Biological process | Protein amino acid N-linked glycosylation | |
| Cellular component | Plasma membrane; integral to plasma membrane | ||
| MYH9 | Biological process | Actin cytoskeleton reorganization; actin filament-based movement; angiogenesis; blood vessel endothelial cell migration; cytokinesis; membrane protein ectodomain proteolysis; monocyte differentiation; platelet formation; protein transport; regulation of cell shape | |
| Cellular component | Cleavage furrow; contractile ring; cytoplasm; cytosol; integrin complex; nucleus; plasma membrane; ruffle; stress fiber | ||
| Molecular function | Actin filament binding; ATPase activity; microfilament motor activity; protein anchor; protein homodimerization activity | ||
| TPM2 | Biological process | Regulation of ATPase activity | |
| Cellular component | Muscle thin filament tropomyosin | ||
| Molecular function | Actin binding; structural constituent of muscle | ||
| ITGA7 | Biological process | Cell-matrix adhesion; muscle organ development; integrin-mediated signaling pathway | |
| Molecular function | Calcium ion binding; protein binding; receptor activity | ||
| MYL2 | Biological process | Cardiac myofibril assembly; heart contraction; negative regulation of cell growth; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis | |
| Cellular component | Sarcomere | ||
| Molecular function | Actin monomer binding; calcium ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle | ||
| SPARCL1 | Biological process | Signal transduction | |
| Molecular function | Calcium ion binding | ||
| ZEB1 | Biological process | Cell proliferation; immune response; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent | |
| Molecular function | Transcription coactivator activity; transcription corepressor activity; transcription factor activity; zinc ion binding | ||