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. 2010 Jan 15;65A(3):209–218. doi: 10.1093/gerona/glp202

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© The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

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Figure 4. — Differential expression of genes representing extracellular matrix proteins and adhesion molecules in three-dimensional gels made from young and aged collagen. Shown are genes that differ by at least 40% in two separate experiments when fibroblasts are placed overnight in young versus aged collagen under identical conditions. Note that genes for ITGA2, ITGA6, ITGA7, ITGA8, ITGB2, ITGB5, MMP-10, MMP-11, MMP-12, MMP-13, and ADAMTS-13 are increased in young collagen and ITGA3, ITGA4, SPARC, TGF-β1, and MMP-3 are increased in aged collagen. ITGA = integrin alpha; ITGB = integrin beta; MMP = matrix metalloproteinase; SPARC = secreted protein acidic and rich in cysteine; TGF-β1 = transforming growth factor-beta 1.