Table 4.
Assessment of stability in human plasmaa
| Condition | Veliparib | |
|---|---|---|
| 8 nM | 800 nM | |
| Freeze-thaw stability (−70°C)b | ||
| Cycle 1 | 97.6 | 102.1 |
| Cycle 2 | 96.6 | 102.9 |
| Cycle 3 | 97.0 | 102.0 |
| Short-term stability (room temperature)b | ||
| Time = 0.5 h | 97.8 | 101.0 |
| Time = 1 h | 101.8 | 102.0 |
| Time = 2 h | 100.2 | 98.9 |
| Time = 4h | 95.9 | 95.3 |
| Time = 6h | 91.7 | 98.0 |
| Autosampler stability (10°C)c | ||
| Time = 2 h | 99.3 | 105.0 |
| Time = 4.4 h | 94.5 | 104.0 |
| Long-term stability (−70°C)b | ||
| Time = 91 days | 102.1 | 103.5 |
| Time = 175 days | 91.4 | 85.9 |
a
Expressed as the mean percentage change from time zero (nominal concentration).
b
Performed in triplicate.
c
Performed repeatedly for 4.4 h with 1 sample.