Table 1.

Mice given rHagB had higher IL-6 and keratinocyte-derived cytokine responses in the nasal wash fluid than mice given boiled rHagB, lipopolysaccharide or phosphate-buffered saline.

Cytokine	rHagB*	rHagB(boiled)‡	LPS§	PBS¶
IL-6	1143.0 (664.4)	519.3 (435.5)	63.0 (11.1)	2.3 (1.9)#
KC	1399.7 (370.7)	1118.0 (291.0)	689.3 (75.5)	219.7 (99.4)#

Data given are the mean (standard error of the mean).

^*LPS content in a 10-μl dose of PBS containing 10 μg rHagB was 19 ng LPS.

^‡Heated at 100°C for 15 min.

^§LPS content in a 10-μl dose of PBS was 19 ng LPS (equivalent to that found in 10 μg rHagB).

^¶LPS content in a 10 μl dose of 0.01 M PBS, pH 7.2 (prepared with pyrogen-free water) was 0.0001 pg LPS.

^#p <0.05, treated vs rHagB control (significance was based on the log ₁₀ transformed data).

KC: Keratinocyte-derived chemokine; LPS: Lipopolysaccharide; PBS: Phosphate buffered saline; rHag: Recombinant hemagglutinin.