Table 2.

Effects of PTX on eNOS phosphorylation at Ser¹¹⁷⁷, NOS and HO activities in lung, and ET-1 levels after CBDL

	Control	3-wk CBDL	3-wk CBDL+PTX
peNOS, fold control	1	2.4±0.3*	1.1±0.4†
NOS activity, pmol·mg protein−1·h−1	4.4±1.1	12.7±0.6*	4.1±1.0†
HO activity, pmol·mg protein−1·h−1	17.6±3.3	27.6±6.8*	25.8±3.9*
Plasma ET-1, pg/ml	8.1±0.2	26.7±3.1*	35.8±3.4*

Values are expressed as means ± SE (n = 5–8 for each group). NOS, nitric oxide synthase; peNOS, phosphorylation of endothelial NOS at Ser¹¹⁷⁷; HO, heme oxygenase; ET-1, endothelin-1.

^*P<0.05 compared with control animals,

^†P<0.05 compared with CBDL animals.