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. 2009 Nov 25;29(47):14942–14955. doi: 10.1523/JNEUROSCI.2276-09.2009

Figure 6.

Figure 6.

Nerve terminal shifting and fragmentation in M2/4−/− dKO NMJs. Confocal views of LAL muscles of 3-week-old (A, B) and 3-month-old (C, D) M2/4−/− dKO mice. Muscles were labeled as described in Figure 1. A, Portions of endplates are commonly unoccupied by terminal arbors (e.g., NMJs marked by arrows, asterisk area in A). B, Some terminal arbors appear to have shifted, leaving previous endplates completely abandoned (e.g., junctions 1 and 2 in B). The synaptic morphology of abandoned endplates closely resembles that of shifted terminal arbors. C, An example of 3-month-old M2/4−/− NMJs exhibiting extensively fragmented clusters of postsynaptic nAChRs. D, Relative distribution of NMJs displaying particular numbers of nAChR patches in M2/4+/+ and M2/4−/− dKO mice. Scale bars: A, B, 20 μm; C, 10 μm.