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A: ERK1/2 phosphorylation following treatment of CHO-KISS1R cells with KP-10 analogs or KP-10 at 1,000 nM for 5 min. Data are from 3 separate studies and results are shown as percentage of basal effect; n = 4–5. B: ERK1/2 phosphorylation following treatment of CHO-KISS1R cells with KP-10 or [dY]1KP-10 at 0.1, 1, 10, 100, 1,000, or 10,000 nM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control (ANOVA with post hoc Tukey's adjustment); n = 3–4.
