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. 2009 Nov 17;298(2):E278–E286. doi: 10.1152/ajpendo.00388.2009

Fig. 2.

Fig. 2.

Effects of 2 wk of pioglitazone treatment on islet morphology (at 12 wk of age). A: representative immunostaining for insulin in pancreatic islet tissue sections from m/m and db/db mice with or without pioglitazone treatment. Effect of pioglitazone on the β-cell ratio (B) and β-cell mass (C). The β-cell ratio and cell mass of each group at 12 wk of age are shown. The β-cell ratio was calculated as a percentage of β-cells to whole islet cells. Open bars, control group; filled bars, pioglitazone group. Data are means ± SE for 5 mice/group. P < 0.05 vs. m/m mice (*) and vs. control group (†).