Fig. 9.

Pharmacological profiles of AE1 E758K-associated ion transport in Xenopus oocytes. Effects of the indicated inhibitors on normalized values of (A) ³⁶Cl⁻ into Xenopus oocytes expressing wild-type AE1; (B) ³⁶Cl⁻ influx into oocytes expressing AE1 E758K; (C) ⁸⁶R⁺ influx into oocytes expressing E758K; (D) SO₄²⁻ influx into oocytes expressing E758K at the indicated bath pH values; (E) ¹⁴C-oxalate influx at pH 5.5 into oocytes expressing wild-type AE1; or (F) ¹⁴C oxalate influx at pH 5.5 into oocytes expressing E758K. H₂O-corrected values are means ± SE for (n) oocytes, and normalized to mean uptake in the absence of inhibitors. Inhibitor concentrations were DIDS (200 μM), Zn²⁺ (200 μM), GsMTx-4 (1 μM), Gd³⁺ (50 μM). *and gray bar indicate P < 0.05 compared to absence of inhibitor (Dunnett's t-test).