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Effect of thalidomide on VEGF-induced Akt phosphorylation in HIMEC. Stimulation of HIMEC with VEGF (50 ng/ml) increased Akt phosphorylation as demonstrated in Western blot analysis. Pretreatment of HIMEC with thalidomide significantly inhibited Akt phosphorylation in a dose-dependent manner, which was similar to the effect of LY294002, a specific PI3K/Akt inhibitor.
