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Rhythmic changes in colonic motility are attenuated in per1per2 knockout mice. A: stool output in per1per2 double-knockout mice (n = 5). B: colonic circular muscle contractility in per1per2 double-knockout mice at ZT1 (n = 4) and ZT13 (n = 4) expressed as AUC (g·s) ± SE. C: intracolonic pressure changes in per1per2 double-knockout mouse under constant darkness.
