Fig. 2.

Pregnancy causes liver growth by hepatocyte hypertrophy. A: representative 5-μm liver sections immunostained for β-catenin. B: number of cells per microscope field. Proportion of Ki-67+ (C) and mitotic (phospho-histone-H3 positive) (D) cells is shown. E: hepatocyte nuclear DNA content from 6 nonpregnant and 6 pregnant mice; 1,500 nuclei were considered from each group. F: protein levels of cell-cycle regulators. Results are shown as means ± SE (n = 6). Studentapos;s t-test, *P < 0.05 compared with nonpregnant animals.