Fig. 2.
8-pCPT-cGMP activates mouse and rat αβγ-ENaC heterologously expressed in oocytes. A and B: representative current traces showing the effects of 8-pCPT-cGMP (CPT-cGMP) on mouse and rat ENaC channels, respectively. Membrane potential was −100 mV. C: summary of current levels. The numbers in parentheses are the number of oocytes examined for each group. *P < 0.05, **P <0.01. D: the ratio of activated and basal currents (ICPT-cGMP/Ibasal) in the presence and absence of 8-pCPT-cGMP. *P < 0.05, **P <0.01.