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Inhibition of cisplatin-induced Bax translocation and cytochrome c release by SAHA. RPTCs were pretreated for 6 h without or with 5 μM SAHA and then incubated for 18 h with 20 μM cisplatin or 20 μM cisplatin plus 1 μM SAHA. Control cells were not exposed to SAHA or cisplatin. The cells were fractionated into cytosolic and mitochondrial fractions for immunoblot analysis of Bax (A) and cytochrome c (B).
