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Suppression of cisplatin-induced Chk2, but not H2AX, phosphorylation by SAHA. RPTCs were pretreated for 6 h without or with 5 μM SAHA and then incubated for 4 or 18 h with 20 μM cisplatin or 20 μM cisplatin plus 1 μM SAHA. Cell lysate was collected for immunoblot analysis of phospho-Chk2, phospho-H2AX, and β-actin.
