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Inhibition of cisplatin-induced p53 activation by SAHA in HCT116 colon cancer cells. HCT116 cells were pretreated for 6 h without or with 5 μM SAHA and then incubated for 4 or 18 h with 80 μM cisplatin or 80 μM cisplatin plus 1 μM SAHA. Cell lysate was collected for immunoblot analysis of phospho-p53 (serine-15) and β-actin (A) or PUMA-α and β-actin (B).
