Table 1.
Summary of the different predictors and their characteristic differences among the methods.
| low sequence complexity | disorder in 3D structures | fully database independent | trained on part of disorder dataset | considers alignment of related sequences | |
|---|---|---|---|---|---|
| SEG [26,42] | + | - | + | - | - |
| CAST [23] | + | - | ~# | - | - |
| IUPred [25] | - | + | - | - | - |
| DisEMBL [22] | - | + | - | + | - |
| DISOPRED2 [24] | - | + | - | + | +§ |
# scores with BLOSUM62
§ through PSI-BLAST
Different concepts of disorder applied during the development of the respective predictors are indicated by markers: "+" indicates that this concept is very relevant for this predictor, "-" indicates that this concept has not been applied and "~" indicates that this concept is indirectly implied.