Fig. 5.
CH-induced pulmonary VSM membrane potential (Em) depolarization persists on exposure to depolarizing concentrations of KCl (A) and is unaltered by ROCK inhibition (B) in Ca2+-permeabilized arteries. A: VSM Em responses to increasing concentrations of KCl [5.4 (basal), 30, and 60 mmol/l] in pressurized, endothelium-disrupted, Ca2+-permeabilized arteries from control and CH rats (n = 4 per group at each KCl concentration). B: VSM Em in arteries from control and CH rats prepared as described in A and treated with HA-1077 (10 μmol/l) or vehicle (n = 3 per group for each treatment). Values are means ± SE. *P < 0.05 vs. control. #P < 0.05 vs. basal. †P < 0.05 vs. 30 mM KCl.