Fig. 5.

Notch4* mutants develop AVM-like lung lesions. A–C: in lungs of control mice, the complete vascular network could be visualized, from the arterial (red arrowheads) to venous (blue arrowheads) circulations, including the intervening capillary network. D–F: in some areas of the Notch4* mutant lungs, the complete vascular network could be seen; however, there were also many areas of poor perfusion. G–L: Notch4* mutants also exhibited many enlarged, tortuous vessels, suggestive of arteriovenous malformations (red arrows). All images are of right cranial lobes. Scale bars, 200 μm (A, D, I, L), 500 μm (B, E, H, K), 2 mm (C, F, G, J).