Fig. 6.

Enlarged vessels seen in Notch4* mutant embryonic lung bud explants. A–D: mutant lung buds develop more large blood vessels and fewer air spaces than controls. Asterisks mark larger blood vessels. Scale bars, 200 μm (A and B), 100 μm (C and D). E: quantification demonstrates a significantly increased number of large vessels and fewer air spaces in the mutants (n = 5/group, counts indicate number of vessels or air spaces per whole organ block of both lungs and are represented as means ± SD).