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Effect of ANG-(1–7), the bradykinin B2 receptor antagonist (B2RA) bradyzine, or ANG-(1–7) plus bradyzine on the NS-induced increase in perfusion pressure in 10- to 12-wk-old SHR mesenteric preparations. Bradyzine was administered in a concentration of 0.1 μM for 15 min alone or in the presence of ANG-(1–7) (0.01 μM), before and during NS. Each bar is the mean increase in perfusion pressure ± SE of 6–7 preparations. ***P < 0.001 compared with control.
