Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Feb 15;207(2):309–318. doi: 10.1084/jem.20090880

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 Fu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — PLCγ1 deficiency impairs thymocyte maturation. (A) PLCγ1 deficiency reduced the percentages of CD4⁺CD8^lo and CD4⁺CD8⁻ thymocytes. Data represent six pairs of mice. (B) PLCγ1 deficiency reduced Th-POK expression in CD4⁺CD8^loCD69⁺ and CD4⁺CD8⁻CD69⁺ thymocytes. Data represent two independent experiments on four Cre/YFP/PLCγ1^fl/− and four Cre/YFP/PLCγ1^+/− mice. (C) PLCγ1 deficiency reduced CD3, CD5, and CD69 expression levels on DP and SP thymocytes. Data represent three pairs of mice. (D) PLCγ1 deficiency blocks positive selection. CD4/CD8 expression profiles on total or T3-70^hi thymocytes from female Cre/PLCγ1^+/−/HY and Cre/PLCγ1^fl/−/HY mice. Data represent three pairs of mice. (E) PLCγ1 deficiency impairs negative selection. CD4/CD8 expression profiles on total or T3-70^hi thymocytes from male Cre/PLCγ1^+/−/HY and Cre/PLCγ1^fl/−/HY mice. Data represent five Cre/PLCγ1^+/−/HY and six Cre/PLCγ1^fl/−/HY mice.