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. 2010 Feb 15;207(2):309–318. doi: 10.1084/jem.20090880

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© 2010 Fu et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — PLCγ1 deficiency results in T cell lymphopenia. (A) CD4/CD8 expression profiles on spleen and lymph node T cells from Cre/PLCγ1^+/− and Cre/PLCγ1^fl/− mice. Data represent six pairs of mice. (B) Percentages of YFP⁺ cells in splenic CD4⁺ and CD8⁺ populations from Cre/YFP/PLCγ1^+/− and Cre/YFP/PLCγ1^fl/− mice. Data represent five pairs of mice. (C) PLCγ1-deficient peripheral T cells displayed higher rates of BrdU incorporation. Data represent three pairs of mice. (D) PLCγ1-deficient T cells showed increased Fas expression. Splenocytes from Cre/YFP/PLCγ1^+/− (thin line) or Cre/YFP/PLCγ1^fl/− (thick line) mice were examined for Fas expression. Dashed lines represent isotype control. Data represent four pairs of mice. (E) PLCγ1-deficient T cells are more susceptible to AICD. 7-AAD⁺ cells are examined in CD4⁺YFP⁺ populations. Each data point is the mean of data derived from three Cre/YFP/PLCγ1^+/− or five Cre/YFP/PLCγ1^fl/− mice. *, P < 0.01.