Table I.

Identification of 13 AML patients bearing an IDH1 R132 or IDH2 R172 mutation

Patient ID	Mutation	Amino acid change	FAB subtype	NPM1 and FLT3 status	Cytogenetic profile	Genotype at relapse	2-HG level (ng/2 × 106 cells)
IDH1 mutations
090108	G/A	R132H	M4	na	Normal	na	2,090
090356	G/A	R132H	na	na	na	na	1,529
0034	C/T	R132C	M5a	Normal	Normal	na	10,285
0086	C/G	R132G	M2	Normal	Normal	na	10,470
0488	C/T	R132C	M0	Normal	Normal	R132C	13,822
8587	G/A	R132H	na	Normal	Normal	na	5,742
8665	C/T	R132C	M1	na	Normal	na	7,217
8741	G/A	R132H	M4	NPM1	Normal	R132H	6,419
9544	C/G	R132G	na	na	Normal	R132G	4,962
747762	G/A	R132H	M1	NPM1	Normal	R132H	8,464
090148	C/T	R132C	M1	na	46, xx, i(7) (p10) [20]	na	na
IDH2 mutations
9382	G/A	R172K	M0	Normal	Normal	na	19,247
0831	G/A	R172K	M1	Normal	Normal	na	15,877
IDH1/2 WT
090239	WT	WT	na	FLT3	Normal	na	112
090158	WT	WT	M2	na	46, XX [15]	na	411
090313	WT	WT	na	na	Normal	na	116

FLT3, FMS-related tyrosine kinase 3 internal tandem duplications. Na indicates that some data were not available for some patients.