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. 2010 Feb 15;207(2):353–363. doi: 10.1084/jem.20091738

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© 2010 Linterman et al.

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Figure 5. — Lack of IL-21R signaling reduces the expression of Bcl-6 in GC B cells. (A) Flow cytometric contour plots indicating the gating strategy for non-GC and GC B220⁺ cells (left) and BCL-6 expression on GL-7⁺ (middle) and Fas⁺ (right) B cells. (B and C) Histogram overlays (B) and bar graphs (C) showing the fluorescence intensity of BCL-6 staining in GC and non-GC B cells as gated in A derived from the CD45.1 Il21r^+/+ or CD45.2 Il21^−/− compartment of CD45.1 Il21r^+/+/CD45.2 Il21r^−/− mixed bone marrow chimeras 6 d after SRBC immunization. The horizontal dashed line highlights the median levels of Bcl-6 found in non-GC B cells. Each set of two bars represents the data from the CD45.1 and CD45.2 compartments of a single mouse. MFI, mean fluorescence intensity.